The value of handhelds in smart environments

The severe resource restrictions of computer-augmented everyday artifacts imply substantial problems for the design of applications in smart environments. Some of these problems can be overcome by exploiting the resources, I/O interfaces, and computing capabilities of nearby mobile devices in an ad-hoc fashion. We identify the means by which smart objects can make use of handheld devices such as PDAs and mobile phones, and derive the following major roles of handhelds in smart environments: (1) mobile infrastructure access point; (2) user interface; (3) remote sensor; (4) mobile storage medium; (5) remote resource provider; and (6) weak user identifier. We present concrete applications that illustrate these roles, and describe how handhelds can serve as mobile mediators between computer-augmented everyday artifacts, their users, and background infrastructure services. The presented applications include a remote interaction scenario, a smart medicine cabinet, and an inventory monitoring applicatio

Gerollte brechende Röntgenfolienlinsen

Gerollte, refraktive Röntgenlinsen bieten eine kostengünstige Alternative zu bestehenden Röntgenoptiken. Dieses Linsenprinzip ist hinsichtlich des Verhältnisses von Brechkraft zu Absorption optimiert und es bietet die Möglichkeit die Messzeit in Diffraktometrieexperimenten wesentlich zu reduzieren. Diese Arbeit beschäftigt sich mit der Entwicklung einer neuen Herstellmethode, der Optimierung der Form sowie der Entwicklung von Simulationsmöglichkeiten für diese Linsen

Gallium arsenide whispering gallery mode resonators for terahertz photonics

As the field of terahertz (THz) photonics advances, we present a monolithic gallium arsenide (GaAs) disk-shaped whispering gallery mode resonator that has potential as a component in THz nonlinear optics. GaAs is a material with significant optical nonlinearity which can be enhanced when the crystal is shaped into a microdisk resonator. A 4-mm-disk-resonator was fabricated using single-point diamond turning and was characterised to obtain a quality (Q) factor of 2.2k at ~150 GHz and 1.4k at ~300 GHz. We also demonstrated the blue-shifting of up to ~0.3 GHz of the THz modes using a block of metal. This post-fabrication degree of freedom could be useful for phase-matching requirements for nonlinear optical processes, such as detection based on optical up-conversion of THz radiation. Such a compact, tunable and efficient device could be integrated into nonlinear photonic platforms for THz generation, manipulation and detection.Comment: 8 pages, 5 figure

Einfluss der Bodenbearbeitung und des Säverfahrens auf die Spross- und Wurzelleistung unterschiedlicher Zwischenfrucht-Mischungen

Zusammenfassung Der Zwischenfruchtbau stellt für den ökologisch wirtschaftenden Betrieb eine wichtige Stellgröße im Management der Bodenfruchtbarkeit dar. Ein hoher Biomasse-Aufwuchs sowie eine intensive Durchwurzelung sind dabei maßgebliche Kenngrößen. Hierbei stellt sich die Frage welches Verfahren zur Bodenbearbeitung und Saat geeignet ist, um einen wirksamen Zwischenfruchtbestand zu etablieren. Im vorliegenden Parzellenversuch wurden sechs verschiedene Zwischenfruchtmischungen mit je zwei unterschiedlichen Bodenbearbeitungs- und Säverfahren kombiniert. Es wurde sowohl der Sprossertrag als auch die Wurzelmasse und -verteilung gemessen. Die Ergebnisse zeigen deutlich, dass die Bestellverfahren einen ertragswirksamen Einfluss auf die Zwischenfrüchte nehmen. Der Sprossertrag wurde maßgeblich vom Säverfahren beeinflusst. Die Grundbodenbearbeitung zeigte keinen signifikanten Effekt auf den Spross- und Wurzelertrag. Die Wurzelverteilung in die Tiefe war dagegen stark von der Bodenbearbeitung abhängig. Wechselwirkungen der Zwischenfruchtmischungen mit dem Bestellverfahren waren erkennbar, ließen sich aber nicht statistisch absichern

Intracardiac thrombus formation after the Fontan operation

AbstractObjectives: Intracardiac thrombus formation is suspected to be a specific sequela after the Fontan operation and is difficult to determine by means of routine transthoracic echocardiography. The aim of our study was to evaluate the occurrence of intracardiac thrombi in the different types of Fontan modifications and to identify predisposing risk factors. Methods: We evaluated 52 patients who had undergone a Fontan-type operation and were free of symptoms regarding thrombosis as determined by transesophageal echocardiography. Results: In 17 (33%) patients thrombus formation could be found without clinical evidence of thromboembolic complications. Neither underlying morphologic disease nor age at operation, type of Fontan operation, sex, follow-up interval, arrhythmias, or laboratory or hemodynamic findings could be identified as predisposing risk factors. Conclusion: In patients having had a Fontan operation with inadequate or without anticoagulation medication, we would recommend routine transesophageal echocardiography to exclude eventual thrombi. Because of the high incidence of thrombi, we suggest oral anticoagulation therapy in all patients. (J Thorac Cardiovasc Surg 2000;119:745-52

Interference of Distinct Invariant Chain Regions with Superantigen Contact Area and Antigenic Peptide Binding Groove of HLA-DR

In the endoplasmic reticulum, MHC class II ab dimers associate with the trimeric invariant chain (li), generating a nine-subunit(abli)3 complex. In the presence of li, the peptide binding groove is blocked, so that loading with self or antigenic peptides can only occur after proteolytic removal of li in specialized post-Golgi compartments. The class 11-associated invariant chain peptide region of li (about residues 81-1 04) is known to mediate binding to class II molecules and blockade of the groove, but this does not exclude additional contact sites for li. Using a set of overlapping li peptides and recombinant soluble li, we demonstrate here that a large segment of Ii encompassing approximately residues 71 to 128 interacts with HLA-DR molecules. The N- and C-terminal regions of this Ii segment appear to bind outside the peptide groove to the contact area for the staphylococcal superantigen Staphylococcus aureus enterotoxin B on the a1 domain. The core region of this segment (residues 95-108)prevents binding of antigenic peptides, probably by interaction with the peptide groove. Occupation of the groove with antigenic peptides abolishes binding not only of the core region, but also that of those Ii peptides that bind outside the groove. These findings suggest the existence of distinct conformational states of class II molecules, with Ii binding preferentially to one form

Diabetic kidney disease in type 2 diabetes: a consensus statement from the Swiss Societies of Diabetes and Nephrology.

Diabetic kidney disease is highly prevalent in patients with type 2 diabetes and is a major cause of end-stage renal disease in Switzerland. Patients with diabetic kidney disease are among the most complex patients in diabetes care. They require a multifactorial and multidisciplinary approach with the goal to slow the decline in glomerular filtration rate (GFR) and cardiovascular morbidity. With this consensus we propose an evidence-based guidance to health care providers involved in the care of type 2 diabetic patients with diabetic kidney disease.First, there is a need to increase physician awareness and improve screening for diabetic kidney disease as early intervention may improve clinical outcomes and the financial burden. Evaluation of estimated GFR (eGFR) and spot urine albumin/creatinine ratio is recommended at least annually. Once it is diagnosed, glucose control and optimisation of blood pressure control with renin-angiotensin system blockers have been recommended as mainstay management of diabetic kidney disease for more than 20 years. Recent, high quality randomised controlled trials have shown that sodium-glucose cotransporter-2 (SGLT2) inhibition slows eGFR decline and cardiovascular events beyond glucose control. Likewise, mineralocorticoid receptor antagonism with finerenone has cardiorenal protective effects in diabetic kidney disease. Glucagon-like peptide-1 (GLP1) receptor agonists improve weight loss if needed, and decrease albuminuria and cardiovascular morbidity. Lipid control is also important to decrease cardiovascular events. All these therapies are included in the treatment algorithms proposed in this consensus. With advancing kidney failure, other challenges may rise, such as hyperkalaemia, anaemia and metabolic acidosis, as well as chronic kidney disease-mineral and bone disorder. These different topics and treatment strategies are discussed in this consensus. Finally, an update on diabetes management in renal replacement therapy such as haemodialysis, peritoneal dialysis and renal transplantation is provided. With the recent developments of efficient therapies for diabetic kidney disease, it has become evident that a consensus document is necessary. We are optimistic that it will significantly contribute to a high-quality care for patients with diabetic kidney disease in Switzerland in the future

Simulation of aperture-optimised refractive lenses for hard X-ray full field microscopy

The aperture of refractive X-ray lenses is limited by absorption and geometry. We introduce a specific simulation method to develop an aperture-optimized lens design for hard X-ray full field microscopy. The aperture-optimized lens, referred to as Taille-lens, allows for high spatial resolution as well as homogeneous image quality. This is achieved by the individual adaptation of the apertures of hundreds of lens elements of an X-ray imaging lens to the respective microscopy setup. For full field microscopy, the simulations result in lenses with both a large entrance and exit aperture and lens elements with smaller apertures in the middle of the lens